Even though one-in-ten people are left-handed, products for the southpaw in your life could still be considered a niche market. Many small businesses claim that PPC doesn’t work for them, or that they can’t compete with the big retailers, but in many cases, that simply isn’t true. Case in point, San Francisco-based left-handed retail specialist Lefty’s.
Freelance writing is such a great industry to get involved in if you want to work remotely. There’s plenty of work available and it’s typically one of the most flexible gigs in terms of scheduling. (You can often do the work whenever and wherever you choose.) Even better, it’s pretty easy to get started with a degree or previous writing experience. Read more at Freelance Writing Jobs for Beginners
Here’s a good example of how lead sales can work in real life: My second website, Life Insurance by Jeff, brings in a ton of traffic from people who are searching the web to find answers to life insurance questions. While I used to have the website set up so I could sell these people life insurance myself, it was a lot of work to process all the different requests and clients. As a result, I started selling the leads I gathered instead.

Many work-from-home jobs that you find will require you to sit at your computer for long periods each day. So it’s super important that you have a comfortable space to work! Even if it’s just a comfortable chair pulled up to an old table that’s the right height, or a spot on your couch, put some thoughtfulness for your future self into your home office. Your body will thank you. (Oh, and make sure it’s in a quiet spot!)

Salvage and resell. Do you love antiques or have a knack for finding valuables at flea markets or yard sales? If you do, it might be time to consider salvaging items for resale – or even scouting out antiques to sell for a profit. While you’ll need to spend quite a bit of time searching for prospects and spend some money buying upfront, you could easily turn a profit if you know what you’re doing.
27. Sponsored/paid posts – Many blogs publish sponsored and paid posts. Sponsored posts are basically just posts about a specific brand, product or service. A company will pay you to publish an article about it. It’s similar with other paid posts as well. Your basically selling the spot for the article on your site. If you decide to take this route, you’ll want to build your traffic before you will get many offers.
There are numerous printing companies that will print your designs onto not just T-shirts, but also hoodies, hats, posters, cushions, bags, and phone cases, to name a few items. These businesses also offer fulfillment services. This means that you promote the merchandise on your own site and once you sell a product the printing company will not only print your design but also send the item directly to the buyer. So all you have to do is concentrate on the marketing and selling of your products, and the fulfillment company will take care of the rest.

Great ideas! I’ve been thinking about starting a home-based business for years but I just never stopped long enough to actually start and I didn’t know what kind of business to pursue. Now I’m ready to get started and you gave me some really good ideas. I really appreciate the links to more information on how to get started in several of these business opportunities. I will definitely look into them.

Cafe Press: This website allows you to create digital designs that can then be sold on the platform. You'll earn a commission for everything that sells and you'll never have to deal with printing, warehousing, customer service and so on. The site has over 2 million independent designers that have created products being sold online here. If you have some graphic design skills, then this is a great potential source for your web-based income. 
Every product cannot be defined by its market niche. The niche market is highly specialized, and aiming to survive among the competition from numerous super companies. Even established companies create products for different niches; Hewlett-Packard has all-in-one machines for printing, scanning and faxing targeted for the home office niche, while at the same time having separate machines with one of these functions for big businesses.[1]
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